Key areas of researchKey area 1: Host-pathogen interactionsOrganizer: Fabien ZOULIM
Key area 2: Vaccinology: immunological basis and technological developmentOrganizer: Jacqueline MARVEL
Key area 3: Structural Biochemistry and therapeutic targets (e.g. Molecular and structural bases for proteins of biomedical interest in the field of infectology)Organizer: Hugues LORTAT-JACOB
Key area 4: EpidemiologyOrganizer: Philippe VANHEMS
Key area 5: Genetic and protein networks of the host cell or the pathogenOrganizer: Pierre JALINOT The presence of the pathogen results in the expression of various different molecules, primarily of the protein and nucleic acid variety, which interact and interfere with a wide range of the host's cell factors, thus modifying the normal operation of the genetic and protein networks. A precise understanding of the mechanisms of infection and the associated pathological effects therefore requires a detailed analysis of a wide variety of cell functions. This key area will support molecular and cell biology research covering the effects of the factors expressed by the pathogen, particularly with respect to the following points: - cell architecture and cell-cell interactions, - signal transduction, - replication and expression of the genome and role of chromatin structure, - arrangement of the nucleus, - maturation and export of the various types of RNA, - modifications and metabolism of proteins. It is anticipated that these studies will produce data which can be used in the therapeutic manipulation of the biology of the host cell with the aim of preventing the replication or the pathogenic effect of the infectious agent. Key area 6: Modeling and Simulation of biological systemsOrganizer: Olivier Gandrillon Contemporary biology generates data not only in enormous quantities, but also of a new kind, making it possible to analyze complex aspects of biological systems. This leads to highly integrated fields of enquiry calling for the use of methods derived from mathematics, computing and physics, and the introduction of systems biology approaches which incorporate experimentation and modeling within a single virtuous circle. To achieve this, the aim of the methodology is to provide an effective interface between the various disciplines in question in order to:
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